منابع مشابه
Aging and oxidation of reactive protein sulfhydryls.
Protein sulfhydryls are potential sites of reversible oxidative modification by S-glutathiolation, and S-nitrosylation, but they are also susceptible to irreversible damage by oxidative conditions. In the absence of adequate antioxidant protection, these reactive sites may become useless because of this irreversible damage. It has recently become possible to directly access the nature and amoun...
متن کاملPathways of peroxynitrite oxidation of thiol groups.
Peroxynitrite mediates the oxidation of the thiol group of both cysteine and glutathione. This process is associated with oxygen consumption. At acidic pH and a cysteine/peroxynitrite molar ratio of < or = 1.2, there was a single fast phase of oxygen consumption, which increased with increasing concentrations of both cysteine and oxygen. At higher molar ratios the profile of oxygen consumption ...
متن کاملReaction of superoxide and nitric oxide with peroxynitrite. Implications for peroxynitrite-mediated oxidation reactions in vivo.
Peroxynitrite (ONOO(-)/ONOOH), the product of the diffusion-limited reaction of nitric oxide (*NO) with superoxide (O(-*)(2)), has been implicated as an important mediator of tissue injury during conditions associated with enhanced *NO and O(-*)(2) production. Although several groups of investigators have demonstrated substantial oxidizing and cytotoxic activities of chemically synthesized pero...
متن کاملOxidation of hypotaurine and cysteine sulphinic acid by peroxynitrite.
Peroxynitrite mediates the oxidation of the sulphinic group of both HTAU (hypotaurine) and CSA (cysteine sulphinic acid), producing the respective sulphonates, TAU (taurine) and CA (cysteic acid). The reaction is associated with extensive oxygen uptake, suggesting that HTAU and CSA are oxidized by the one-electron transfer mechanism to sulphonyl radicals, which may initiate an oxygen-dependent ...
متن کاملEnhancement by glucose of low density lipoprotein-oxidation by peroxynitrite.
Oxidation of low density lipoprotein (LDL) by copper ions is not influenced by glucose in a concentration range between 1 and 20 mM. LDL-oxidation by peroxynitrite or the simultaneous action of nitrogen monoxide and superoxide, produced by morpholino-sydnonimine (SIN-1) is considerably enhanced by typical hydroxyl-radical scavengers such as formate or mannitol and by glucose. Since both free ra...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1991
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(20)64313-7